Fractal dimension (FD) is a feature which is widely used to characterize medical images. Previously, researchers have shown that FD separates important classes of images and provides distinctive information about texture. The authors analyze limitations of two principal methods of estimating FD: box-counting (BC) and power spectrum (PS). BC is ineffective when applied to data-limited, low-resolution images; PS is based on a fractional Brownian motion (fBm) model-a model which is not universally applicable. The authors also present background information on the use of fractal interpolation function (FIF) models to estimate FD of data which can be represented in the form of a function. They present a new method of estimating FD in which multiple FIF models are constructed. The mean of the FD's of the FIF models is taken as the estimate of the FD of the original data. The standard deviation of the FD's of the FIF models is used as a confidence measure of the estimate. The authors demonstrate how the new method can be used to characterize fractal texture of medical images. In a pilot study, they generated plots of curvature values around the perimeters of images of red blood cells from normal and sickle cell subjects. The new method showed improved separation of the image classes when compared to BC and PS methods.
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