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A Novel High-Sensitivity Cardiac Multibiomarker Detection System Based on Microfluidic Chip and GMR Sensors

机译:基于微流控芯片和GMR传感器的新型高灵敏度心脏多生物标志物检测系统

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摘要

We have developed a novel cardiac multibiomarker detection system, wherein cardiac biomarkers NT-proBNP and cTnI could be detected simultaneously in 20 min. The lower limits of detection of NT-proBNP and cTnI were 0.33 and 1.43 pg/ml, respectively. Furthermore, based on a microfluidic chip and a giant magnetoresistance sensor, the detecting system was realized in a small platform to decrease the manufacturing cost and the difficulty of operation. In addition, owing to the usage of the superparamagnetic nanoparticles of suitable diameter and bovine serum albumin blocker in nanoparticles solution, the system achieved a high signal-to-noise ratio in the whole dynamic range. This magnetic immunoassay system can be adapted to detect a variety of clinically important biomolecules in human samples and provide accurate information to diagnose human diseases.
机译:我们已经开发了一种新颖的心脏多生物标志物检测系统,其中可以在20分钟内同时检测到心脏生物标志物NT-proBNP和cTnI。 NT-proBNP和cTnI的检测下限分别为0.33 pg / ml和1.43 pg / ml。此外,基于微流体芯片和巨型磁阻传感器,在小型平台上实现了检测系统,从而降低了制造成本和操作难度。此外,由于在纳米颗粒溶液中使用了合适直径的超顺磁性纳米颗粒和牛血清白蛋白阻滞剂,该系统在整个动态范围内实现了很高的信噪比。该磁免疫测定系统可适于检测人类样品中多种临床上重要的生物分子,并提供准确的信息以诊断人类疾病。

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