Magnetoresistive Biosensors for On-Chip Detection and Localization of Paramagnetic Particles

摘要

This paper presents the design and the implementation of an on-chip magnetoresistive sensors array for cell detection and localization. Giant magnetoresistance (GMR) sensors have been used due to their high sensitivity and resolution. A new calibration and localization algorithm has been coded and implemented. In order to generate the required homogenous magnetic field, a custom 3-D printed Halbach cylinder has been simulated and characterized. The system includes sensory and electronic boards to collect the data and to transfer them to a computing server. The experimental results are displayed in a visual interface. Ferrofluid is used to model and simulate the magnetic field change of the cell. This paper demonstrates a 4 × 4 sensor array and provides a step toward the miniaturized on-chip magnetoresistive-based cell detection and localization for portable diagnostics applications.