Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome

O. Valkenburg15 A.G. Uitterlinden23 D. Piersma2 A. Hofman3 A.P.N. Themmen2 F.H. de Jong2 B.C.J.M. Fauser4 and J.S.E. Laven1

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Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome

机译：GnRH和促性腺激素受体的遗传多态性影响多囊卵巢综合征的表型。

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BACKGROUND Polycystic ovary syndrome (PCOS) is a complex genetic disorder. Multiple functional polymorphisms have been identified in genes that regulate the hypothalamic–pituitary–gonadal (HPG) axis that regulates ovarian function. The present study aims to examine the influence of genetic variants of the HPG-axis on the severity of clinical features of PCOS and disease susceptibility.

机译：背景技术多囊卵巢综合征（PCOS）是一种复杂的遗传性疾病。在调节下丘脑-垂体-性腺（HPG）轴（调节卵巢功能）的基因中已鉴定出多种功能多态性。本研究旨在检查HPG轴的遗传变异对PCOS临床特征的严重性和疾病易感性的影响。

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《Human Reproduction》 |2009年第8期|p.2014-2022|共9页
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O. Valkenburg15 A.G. Uitterlinden23 D. Piersma2 A. Hofman3 A.P.N. Themmen2 F.H. de Jong2 B.C.J.M. Fauser4 and J.S.E. Laven1;
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1Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Room HS508, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands 2Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands 3Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands 4Department of Reproductive Medicine and Gynaecology, University Medical Center, Utrecht, The Netherlands;

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1. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome. [J] . Valkenburg O, Uitterlinden AG, Piersma D Human Reproduction . 2009,第8期

机译：GnRH和促性腺激素受体的遗传多态性影响多囊卵巢综合征的表型。
2. Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome. [J] . Valkenburg O, Uitterlinden AG, Themmen AP, Human Reproduction . 2011,第10期

机译：糖皮质激素受体的遗传多态性可能影响无排卵性多囊卵巢综合征女性的表型。
3. Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome [J] . O. Valkenburg, A.G. Uitterlinden, A.P. Themmen, Human Reproduction . 2011,第10期

机译：糖皮质激素受体的遗传多态性可能影响无排卵性多囊卵巢综合征女性的表型
4. ASSOCIATION BETWEEN CYP11A1 GENE SNP RS4077582 POLYMORPHISM AND POLYCYSTIC OVARY SYNDROME IN CHINESE WOMEN [C] . Zhang Chengwei, Zhang Xinlin, Xu Pei, Progress on post-genome technologies and modern natural products . 2011

机译：CYP11A1基因SNP RS4077582多态性与多囊卵巢综合征的相关性
5. A Review of Genetic Polymorphisms in the Receptors for Gonadotropic and Sex Hormones in Polycystic Ovary Syndrome [D] . Rudolph, Sara 2017

机译：多囊卵巢综合征性激素和性激素受体的遗传多态性综述。
6. Brief Report: Increased Frequency of the Anti-Müllerian-Inhibiting Hormone Receptor 2 (AMHR2) 482 AG Polymorphism in Women With Polycystic Ovary Syndrome: Relationship to Luteinizing Hormone Levels [O] . Neoklis A. Georgopoulos, Eleni Karagiannidou, Vasiliki Koika, -1

机译：简要报告：多囊卵巢综合征女性中抗苗勒管抑制激素受体2（AMHR2）482 A G多态性的频率增加：与促黄体激素水平的关系
7. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome [O] . O. Valkenburg, A.G. Uitterlinden, D. Piersma, 2009

机译：GNRH和促性营养激素受体的遗传多态性影响多囊卵巢综合征的表型

Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome

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