SELECTED ORAL COMMUNICATION SESSION, SESSION 54: EARLY PREGNANCY DISORDERS, Tuesday 5 July 2011 17:00 – 18:00

摘要

Introduction: Previously we have reported a tissue-specific loss of methylation in KCNQ1OT1 (11p15) and PLAGL1 (6q24) in first-trimester spontaneous abortions. An addition we have shown that errors of imprinting maintaining mechanisms on maternal chromosomes during embryo development may be among molecular processes responsible for recurrent pregnancy loss. The aim of the present investigation was identify differential methylation of imprinting genes in samples of first-trimester spontaneous abortions from women who have recurrent pregnancy loss.