Isolation of secondary metabolites from Stenochlaena palustris stems and structure-activity relationships of 20-hydroxyecdysone derivatives on antitermite activity

摘要

Stenochlaena palustris is an edible fern, -belonging to the Blechnaceae family and is called kelakai in South Kalimantan, Indonesia. The effects of fractions of S. palustris stems and isolated constituents on termite mortality and paper disc consumption by Coptotermes curvignathus have been studied. Treatment of the ethyl acetate (EtOAc) fraction on paper discs greatly induced death of C. curvignathus within 6 days. Our phytochemical investigation of S. palustris stems led to the isolation of major constituents and 20-hydroxyecdysone exerted the highest termiticidal activity, followed by stenopalustroside A and ajugasterone C. Moreover, the structureactivity relationships (SAR) of synthetic derivatives from 20-hydroxyecdysone and ajugasterone C suggested that a 2,3-diol has considerable effect on their antitermite properties against C. curvignathus.