Efficient Synthesis of [1,3]Oxazino[3,2-f]phenanthridine Derivatives by a Novel 1,4-Dipolar Cycloaddition Involving a Phenanthridine–Dimethyl Acetylenedicarboxylate Zwitterion and Aromatic Aldehydes

摘要

An efficient synthesis of [1,3]oxazino[3,2-f]phenanthridine derivatives via a three-component reaction of phenanthridine, dimethyl acetylenedicarboxylate (DMAD), and aromatic aldehydes is described. This novel method is complementary to the classical Huisgen 1,4-dipolar cycloaddition in that it is well-suited to the preparation of [1,3]oxazino[3,2-f]phenanthridines.