Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation

摘要

Conclusions: An increase in left ventricular total wall thickness precedes IL-2 positive acute rejection after heart transplantation. Thus, cardiac allograft rejection accompanied by intragraft IL-2 mRNA expression may be indicative of more severe rejection episodes. Objective: To assess whether diastolic graft function is influenced by intragraft interleukin 2(IL-2)mes- Senger RNA(mRNA)expression in rejection cardiac allografts. Design: 16 recipients of cardiac allografts were monitored during the first three months after Transplantation. The presence of IL-2 mRNA in endomyocardial biopsies(n = 123)was measured by Reverse transcriptase polymerase chain reaction.