First Report on HLA-DPB1 Gene Allelic Distribution in the General Lebanese Population

摘要

Aims: Interest in the importance of the HLA-DPB2 gene has increased lately, especially in transplantation outcomes in addition to other HLA CII molecules. This is the first study that assesses HLA-DPB2 typing among healthy Lebanese individuals. Methods: The HLA-DPB2 alleles were detected using the polymerase chain reaction/sequence-specific priming method and our study included 130 individuals. HLA-DPB2 was determined in different ethnic groups and in relation to various clinical entities. Results: We compared our data with the existing literature and found an interesting similarity between the Lebanese and Greek populations with highly specific alleles not reported in other communities. Conclusion: Our study will form the basis for further research to study the correlation between HLA-DPB2 and various clinical entities as well as a primer study for other transplantation centers.