Perfluoroalkylated substances (PFAS) enhance the activity of the hormone receptors ERα and ERβ

摘要

Perfluoroalkylated substances (PFAS), including Perfluo-rooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are used for the fabrication of surfaces with water-and dirt-repellent properties. Due to the fact that PFOA and PFOS are highly persistent in the environment and revealed reprotoxic properties, the use of PFOS was restricted in 2009 and a restriction program for PFOA was initiated in 2013. Therefore, the industry switches to alternative substances to PFOA and PFOS with a shorter carbon chain length or a modified structure. In contrast to PFOA and PFOS only few toxicological data are available for their substitutes.