Modulation of hydroxy- and epoxy-PUFA formation by food polyphenols

摘要

Polyphenols (a large group of secondary plant metabolites) can lead to food-drug-interactions, causing side effects of pharmaceuticals by modulation of cytochrome-P450-enzyme (CYP) activity. One of the best known examples is the flavonoid naringenin: by an inhibition of CYP3A4, resulting in a prolonged half-life of several drugs, this polyphenol contained in grapefruit can lead to toxicity of drugs predominantly metabolized by this CYP isoform. However, the effects of food ingredients on CYP families involved in the metabolism of endogenous Substrates like fatty acids (FA) have been sparsely investigated so far.