Molecular profiling in the age of cancer genomics

摘要

In this new era of cancer genomics, large-scale queries of whole genomic characteristics arennow possible not only for research and biological understanding, but also for molecularnprofiling in the context of patient management and care. Here, we will examine genomic,ntranscriptomic and proteomic methods of characterizing tumors that may play a role in earlyndiagnosis, classification, prognosis, therapeutic guidance and recurrence surveillance duringnthe entire progression of the disease and treatment cycle. We examine all the technologicalnadvances and biological discoveries that enable new exciting frontiers of molecular profiling,nand also provide a glimpse of emerging and future applications of these methods in anclinical setting.