Effects of Chronic Adiministration of Sibutramine on Body Weight, Food Intake and Motor Activity in Neonatally Monosodium Glutamate-Trreated Obese Female Rata: Relationship of Antiobesity Effect with Monoamines

摘要

When the hypothalamic ventromedial nucleus and accurate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index(body weight ~1/3body length)and in retroperitoneal far as well as decreases in spontaneous motor activity, food consumption and growth hormone secretion function associated with hypothalamic low body length obesity(monosodium glutamate- treated obesity; MSG-OB)were observed as these rats grew.