Genetic dissection of energy-metabolism related traits with mouse inter-subspecific consomic strains

摘要

B6-ChrN~(MSM) consomic strains were generated by substituting every chromosome of a standard laboratory strain C57BL/6J by a chromosome counterpart of MSM/Ms strain derived from Japanese wild mouse. We performed systematic phenotyping of the B6-ChrN~(MSM) strains and two parental strains C57BL/6J and MSM/Ms, focusing on metabolism-related complex traits. This study successfully detected a large number of significant QTLs for metabolism-related traits. All the results showed that the established inter-subspecific consomic mouse strains would provide a powerful tool to identify latent genetic factors underlying the energy-metabolism related complex traits. Based on the strain difference, we intend to explore genes underlying the complex obesity traits by using F2 crosses of C57BL/6J and a relevant consomic strain as well as subconsomic strains derived from the consomic strain.