Initial Arthritic Lesions Induced by Immunization with Type Ⅱ Collagen in Lewis Rats

摘要

Lewis rats were immunized with an intradermal injection of type Ⅱ collagen to study the time course of arthritic lesions. Serum type Ⅱ collagen antibody was detected 9 days after immunization. Increased paw volume in the hind limbs was noted on day 11. Histopathologically, proliferation of synovial lining cells was observed on day 11 and typical lesions similar to those of human rheumatoid arthritis were noted on day 18.