Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarction

摘要

Evidence has shown that pro-inflammatory cytokines, especially TNF-α, are involved in the inflammatory response in the remodelling process after myocardial infarction (MI). Although IL-10, an anti-inflammatory cytokine, has been shown to antagonize some of the deleterious effects of TNF-α, little is known about its role in post-MI left ventricular (LV) dysfunction. The aim of the present study was to investigate whether a therapy with rhIL-10 could be beneficial in an animal model of post-MI heart failure (HF).