Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth muscle cell caveolae numbers and altered AT₁- and epidermal growth factor-receptor function

摘要

Aims We previously showed that enhanced myogenic constriction (MC) of peripheral resistance arteries involves active AT₁ receptors in chronic heart failure (CHF). Recent data suggest both transactivation of EGF receptors and caveolae-like microdomains to be implicated in the activity of AT₁ receptors. Thus, we assessed their roles in increased MC in mesenteric arteries of CHF rats.