Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension

Eugenia Gkaliagkousi1 Valerie Corrigall2 Silke Becker1 Patricia de Winter1 Ashish Shah1 Chrysanthos Zamboulis3 James Ritter1 and Albert Ferro1*

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Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension

机译：血小板一氧化氮减少导致高血压患者循环单核细胞-血小板聚集增加

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Aims The aim of this study was to determine the effect of blood pressure (BP) on platelet nitric oxide (NO) signalling and on formation of circulating monocyte-platelet aggregates (MPA), as well as the role of platelet NO in modulating MPA in hypertension.

机译：目的本研究旨在确定血压（BP）对血小板一氧化氮（NO）信号传导和循环单核细胞-血小板聚集体（MPA）形成的影响，以及血小板NO在调节MPA中的作用。高血压。

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《European Heart Journal》 |2009年第24期|p.3048-3054|共7页
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Eugenia Gkaliagkousi1 Valerie Corrigall2 Silke Becker1 Patricia de Winter1 Ashish Shah1 Chrysanthos Zamboulis3 James Ritter1 and Albert Ferro1*;
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1Department of Clinical Pharmacology, Cardiovascular Division, King's College London, 3.07 Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK 2Department of Rheumatology, King's College London, Guy's Campus, London, UK 32nd Prop. Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;

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1. Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension. [J] . Gkaliagkousi E, Corrigall V, Becker European Heart Journal: The Journal of the European Society of Cardiology . 2009,第24期

机译：血小板一氧化氮的减少有助于高血压中循环单核细胞-血小板聚集的增加。
2. Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection [J] . Hua Liang, Zhaojun Duan, Dan Li, 中国免疫学杂志（英文版） . 2015,第004期

机译：较高的循环单核细胞-血小板聚集体水平与病毒血症和HIV-1感染中sCD163水平升高有关
3. Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD 163 levels in HIV- 1 infection [J] . Hua Liang1, Zhaojun Duan2, Dan Li1, 细胞与分子免疫学：英文版 . 2015,第004期

机译：循环单核细胞 - 血小板聚集体的较高水平与病毒血症相关，并在HIV-1感染中增加了SCD 163水平
4. Essential Hypertension:Elastase, Nitric Oxide Metabolites and Oxidative Status [C] . R. Lo Presti, C. Carollo, G. Mule, Conference of the European Society for Microcirculation . 2008

机译：必需的高血压：弹性蛋白酶，一氧化氮代谢物和氧化地位
5. Endothelial nitric oxide synthase is essential for circulating angiogenic cell biology and ischemia-directed homing. [D] . Everaert, Bert. 2012

机译：内皮型一氧化氮合酶对于循环血管生成细胞生物学和缺血导向的归巢至关重要。
6. Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies: Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension [O] . Adeleye J. Afolayan, Annie Eis, Maxwell Alexander, -1

机译：肺部疾病中的生物标记物：从发病机理到预测到新疗法：内皮型一氧化氮合酶的表达和功能降低导致持续性肺动脉高压的胎儿羔羊线粒体生物发生和氧化应激受损
7. Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension [O] . Eugenia Gkaliagkousi, Valerie Corrigall, Silke Becker, 2009

机译：降低的血小板一氧化氮有助于增加高血压中的循环单核细胞 - 血小板聚集体
8. Increased Platelet Reactivity and Circulating Monocyte-Platelet Aggregates in Patients with Stable Coronary Artery Disease [R] . Furman, M. I. , Benoit, S. E. , Valeri, C. R. , 1996

机译：稳定性冠状动脉疾病患者血小板反应性和循环单核细胞 - 血小板聚集性增加

Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension

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