Biomimetic solid-phase microextraction to predict body residues and toxicity of chemicals that act by narcosis

摘要

A biomimetic extraction technique using solid-phase microextraction(SPME) fibers has been developed for the risk assessment of contaminants with a narcotic mode of action. Our goal is to apply this technique in the future for the prediction of total baseline toxicity of environmental water and effluent samples. Validation of this method requires establishing the relationship between contaminant accumulation and toxicity in biota and accumulation in the surrogate solid phase (the SPME fiber coating). For this purpose, we determined the median lethal concentration(LC50) values for Chironomus repairs midge larvae exposed to Two halogenated aromatic compounds separately and measured body residues in the exposed larvae.