Zizyphus jujuba and Origanum majorana extracts protect against hydroquinone-induced clastogenicity

摘要

Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective effect of Zizyphus jujuba and Origanum majorana extracts against HQ-induced genotoxicity in male mice. Five groups of mice included the control group, HQ-treated group, and the groups treated with the extracts alone or in combination with HQ. The results indicated that treatment with HQ resulted in significant clastogenetic effects and histological changes typical to those reported in the literature. Both extracts exhibited a protection against HQ-induced cytogenesis and histological changes. Moreover, Z. jujuba extract was effective than O. majorana extract. It could be concluded that both extracts are useful especially for people who are occupationally exposed to benzene or its metabolites.