Toxic effects of selected trace elements contained in make-ups on female university students in Nigeria

摘要

Arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), beryllium (Be), nickel (Ni), selenium (Se), and thallium (Tl) are reportedly notorious toxic contents of make-ups, with potential to cause cancer and chronic kidney disease, warranting investigation on their toxic effects. One hundred female university students were randomly selected as consistent users of make-ups for upward of 3 years. The serum/urine levels of the 8 elements were regressed against the kidney functions (estimated glomerular rate, eGFR) of the subjects. At coefficient of − 0.009, As had insignificant (0.518) level. The coefficient for Cd was − .155 and insignificant (0.423). At coefficient of − 039, Pb level was insignificant (0.595). The coefficient, 0.061, for Hg was insignificant (0.462). At − 1.585, the coefficient of Be was insignificant (0.292). The coefficient for Ni, 1.384, was insignificant (0.354). At − .002, the coefficient of Se was insignificant (0.635). The coefficient, 0.039, for Tl was significant at 5% (0.015). This finding internally validated the mean serum Tl level, 201.4900 ± 20.63316 μg/L, which was much higher than the normal level of < 2 µg/L and within the toxic range of > 200 µg/L. A policy is needed to address the use of make-ups containing Tl.