Allergic Contact Sensitizing Chemicals as Environmental Carcinogens

摘要

Chemicals that were bioassayed by the National Toxicology Program (NTP) and that also produce allergic dermatitis (ACD) in humans were evaluated for their tumorigenic characteristics. The impe- tus for the study was that most contact sensitizers, i.e., those that produce ACD, and genotoxic car- cinogens are chemically similar in that they are electrophilic, thereby producing adducts on macro- molecules including protein and DNA. This similarity in chemical behavior suggests that many con- tact sensitizers might be environmental carcinogens.