The molecular electrostatic potential of the B-DNA helix. VL The regions of the base pairs in poly (dG.dC) and poly (dA.dT)

摘要

The evaluation of the electrostatic molecular potential at important nu-cleophilic sites of the purine and pyrimidine bases in poly(dG.dC) and poly (dA.dT) and of the evolution of the potential through the series free bases-nucleosides-nucleotides-single polynucleotide helices-double helices enables the interpretation of the evolution of the corresponding reactivity of the bases towards a series of electrophilie carcinogenic and mutagenic reactants.