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Thiazolidinediones Exert Different Effects on Insulin Resistance between Dexamethasone-Treated Rats And Wistar Fatty Rats

机译:噻唑烷二酮对地塞米松治疗的大鼠和Wistar肥胖大鼠的胰岛素抵抗具有不同的作用

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摘要

ew determined the in vivo effects of thiazolidinediones on insulin resistance induced by dexamethasone (Dx), as well as that observed in Wistar fatty (WF) rats, using glucose clamp technique to measure glucose uptake were treated with Dx (0.5 mg/kg/day) for 7 days. Pioglitazone (P) or troglitazone (T) was coadministered orally for the same period at 10 and 200 mg/kg/day, respectively.
机译:通过葡萄糖钳技术测量Dx(0.5 mg / kg /天),可以确定噻唑烷二酮对地塞米松(Dx)诱导的胰岛素抵抗以及在Wistar脂肪(WF)大鼠中观察到的胰岛素抵抗的体内作用。 )的7天。吡格列酮(P)或曲格列酮(T)分别以10 mg / kg / kg和200 mg / kg / day的口服剂量同时服用。

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