IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese

AKIRA KASUGA; AKIRA SHIMADA; YUKAKO OZAWA

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IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese

机译：在日本1型糖尿病中，IgG1是抗谷氨酸脱羧酶抗体的主要亚类。

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Autoantibody against glutamic acid decarboxylase (GADA) is a highly sensitive predictor of insulin-de- pendency in adult diabetic patients as well as yound individuals. A considerable number of diabetics who do not reach the insulin-dependent stage have this antibody. Recently, type 1 diabetes has been thought to be caused by T helper 1 (Th1)-type autoimmunity based on studies in non-obese diabetic mice, but it is still difficult to investigate antigen-specific T-cell function in human type 1 diabetes.

机译：谷氨酸脱羧酶自身抗体（GADA）是成年糖尿病患者和青年人胰岛素依赖的高度敏感的预测因子。尚未达到胰岛素依赖期的相当多的糖尿病患者都具有这种抗体。最近，根据非肥胖型糖尿病小鼠的研究，据认为1型糖尿病是由T辅助1（Th1）型自身免疫引起的，但在人1型糖尿病中研究抗原特异性T细胞功能仍然很困难。

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《Endocrine journal》 |2000年第1期|p.57-62|共6页
作者
AKIRA KASUGA; AKIRA SHIMADA; YUKAKO OZAWA;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Type 1 diabetes; GAG antibody; IgG subclass;

机译：1型糖尿病;GAG抗体;IgG亚类;
入库时间 2022-08-18 01:36:08

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专利

1. IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese [J] . AKIRA KASUGA, AKIRA SHIMADA, KAZUHIKO OYA, Endocrine journal . 2000,第1期

机译：IgG1是日本1型糖尿病中谷氨酸脱羧酶抗体的主要亚类
2. Increased diagnosis of autoimmune childhood‐onset Japanese type?1 diabetes using a new glutamic acid decarboxylase antibody enzyme‐linked immunosorbent assay kit, compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit [J] . Shigetaka Sugihara, Ichiro Yokota, Tokuo Mukai, Journal of diabetes investigation. . 2020,第3期

机译：与先前使用的谷氨酸脱羧酶抗体放射线菌加入免疫汞型试剂盒相比，使用新的谷氨酸脱羧酶抗体酶联酶联免疫吸附试剂盒增加了自身免疫性儿童发病日本型α1糖尿病
3. IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes [J] . Dereke Jonatan, Nilsson Charlotta, Strevens Helena, Clinical immunology: The official journal of the Clinical Immunology Society . 2016,第1期

机译：IgG4亚类谷氨酸脱羧酶抗体（GADA）与罹患1型糖尿病的风险降低以及GADA阳性妊娠糖尿病中C肽水平升高相关
4. Stable recombinant expression and functional identity of the anti HIV-1 monoclonal antibody 2F5 after IgG3/IgG1 subclass switch in CHO-cells [C] . R.KUNERT, W.STEINFELLNER, A.ASSADIAN Annual Meeting of the European Society of Animal Cell Technology . 1999

机译：抗HIV-1单克隆抗体2F5稳定的重组表达和抗HIV-1单克隆抗体2F5在CHO - 细胞中的IgG3 / IgG1亚类开关后
5. The role of MHC class II molecules in type I diabetes: An analysis of presentation of glutamic acid decarboxylase 65 by the diabetes-associated HLA-DQ8 molecule. [D] . Herman, Ann Elizabeth. 2000

机译：MHC II类分子在I型糖尿病中的作用：与糖尿病相关的HLA-DQ8分子对谷氨酸脱羧酶65表达的分析。
6. Increased diagnosis of autoimmune childhood‐onset Japanese type 1 diabetes using a new glutamic acid decarboxylase antibody enzyme‐linked immunosorbent assay kit compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit [O] . Shigetaka Sugihara, Ichiro Yokota, Tokuo Mukai, 2020

机译：与以前使用的谷氨酸脱羧酶抗体放射免疫分析试剂盒相比使用新型谷氨酸脱羧酶抗体酶联免疫吸附分析试剂盒可增强对儿童自身免疫性日本1型糖尿病的诊断
7. Increased diagnosis of autoimmune childhood‐onset Japanese type 1 diabetes using a new glutamic acid decarboxylase antibody enzyme‐linked immunosorbent assay kit, compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit [O] . Shigetaka Sugihara, Ichiro Yokota, Tokuo Mukai, 2019

机译：使用新的谷氨酸脱羧酶抗体酶联免疫吸附试剂盒增加了自身免疫儿童发病日本型1型糖尿病的诊断增加，与先前使用的谷氨酸脱羧酶抗体放射免疫汞算子

IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese

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