Plasma Angiotensin II, Renin Activity and Serum Angioten- sin-Converting Enzyme Activity in Non-Insulin Dependent Diabetes Mellitus Patients with Diabetic Nephropathy

摘要

The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic com- plications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-converting enzyme (ACE) activity were measured in 45 non-insulin dependent diabetes mellitus (NIDDM) patients and 15 healthy non-diabetic controls. Diabetics were subdivided into 15 normoalbuminuric NIDDM subjects, 15 NIDDM patients with microalbuminuria and 15 diabetics with macroalbuminuria.