A case of macroprolactinoma with subclinical grwoth hormone production

摘要

We described a rare case of macroprolactinoma with subclinically synchronous growth hormone(GH) production. A 59-year-old man with a giant adenoma in his pituitary had elevated serum prolactin(PRL)and in- sulin-like growth factor(IGE)-I levels, despite normal levels of basal GH. Serum GH levels were paradoxically in- creased in response to an intravenous administration of thyrotropin-releasing hormone(TRH). Prolonged exposure to glucose as a result of oral glucose tolerance testing(oGTT)failed to decrease GH levels. Two-week treatment with cabergoline, a dopamine D2 receptor agonist, decreased serum PRL and GH levels, and size of the tumor.