The insulin secretion-sensitivity index-2 (ISSI-2) and the measurement of beta-cell function in women with gestational diabetes

摘要

In their recent report on beta-cell dysfunction in Asian women with gestational diabetes (GDM) [1], Saisho and colleagues assess beta-cell function from the oral glucose tolerance test (OGTT) using a construct defined as the product of (i) insulin secretion, measured by the ratio of the area-under-the-insulin-curve to the area-under-the-glucose curve (AUC_(ins/glu)), and (ii) insulin sensitivity, measured by the IS_(OGTT) index of Matsuda and DeFronzo. They present a graphical representation of the hyperbolic relationship between AUC_(ins/glu) and IS_(OGTT), and describe the product of these two measures as the disposition index.