Clinical Significance of a Sensitive Assay for thyroid- Stimulating Antibodies in Graves' Disease Using Polyethylene glycol at High Concentrations And Porcine Thyroid Cells

摘要

The Inui and Ochi group recently reported that cAMP production by porcine thyroid cells (PTC) was augmented more by polyethylene glycol (PEG) 22.5/10 precipitated fractions from almost all graves' sera than those of PEG 12.5/100. In the present study, thyroid stimulating immunoglobulin (TSI) activity was determined with PTC and prepared crude Ig fractions precipitated by two different concentrations of PEG (final concentrations 13./100 and 22.5/100) from sera obtained from 117 Grave's patients.