Hydractinia echinata test-system. IV. Toxic synergism of human pharmaceuticals in mixtures with iodoform

摘要

The structure-toxicity relationships for a series of singular human stomatological pharmaceuticals preparations and in mixture with Iodoform on Hydractinia echinata were obtained and their synergism was analyzed through the Metamorphosis Reduction Concentration (MRC50) within the "Koln model". The differences manifested between the total and individual components of the samples and mixtures, associated with toxic versus non-toxic synergism, are dependent on three essential factors of synthesis (the nature, the concentration and the number) besides manifested isotoxicity of the given components. The method represents a practical alternative useful for the reduction of experimental tests on animal to the lowest possible level, in accordance to the `3Rs' (reduce, reuse and recycle) integrative concept. (C) 2016 Elsevier Inc. All rights reserved.