Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes

K. Hara; M. Horikoshi; H. Kitazato; T. Yamauchi; C. Ito; M. Noda; J. Ohashi; P. Froguel; K. Tokunaga; R. Nagai; T. Kadowaki

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Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes

机译：脂联素受体编码基因的多态性与2型糖尿病之间没有关联

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Secreted by adipocytes, adiponectin is a hormone that acts as an antidiabetic and anti-atherogenic adipokine. We recently cloned the genes encoding two adiponectin receptors (ADIPOR1 and ADIPOR2). The aim of this study was to examine whether ADIPOR1 and/or ADIPOR2 play a major role in genetic susceptibility to insulin resistance or type 2 diabetes in the Japanese population.

机译：脂联素是由脂肪细胞分泌的，是一种抗糖尿病和抗动脉粥样硬化的脂肪因子。我们最近克隆了编码两个脂联素受体（ADIPOR1和ADIPOR2）的基因。这项研究的目的是检查ADIPOR1和/或ADIPOR2是否在日本人群中对胰岛素抵抗或2型糖尿病的遗传易感性中起主要作用。

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来源
《Diabetologia》 |2005年第7期|1307-1314|共8页
作者
K. Hara; M. Horikoshi; H. Kitazato; T. Yamauchi; C. Ito; M. Noda; J. Ohashi; P. Froguel; K. Tokunaga; R. Nagai; T. Kadowaki;
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作者单位

Department of Metabolic Diseases Graduate School of Medicine University of TokyoDepartment of Clinical Bioinformatics Graduate School of Medicine University of TokyoCore Research for Evolution Science and Technology (CREST) Japan Science and Technology Corporation (JST);

Department of Metabolic Diseases Graduate School of Medicine University of Tokyo;

Institute for Diabetes Care and Research Asahi Life Foundation;

Department of Metabolic Diseases Graduate School of Medicine University of Tokyo;

Hiroshima Atomic Bomb Casualty Council Health Management Center;

Department of Endocrinology and Metabolism Toranomon Hospital;

Department of Human Genetics Graduate School of Medicine University of Tokyo;

Institute of Biology—CNRS 8090 Pasteur Institute of LilleImperial College Genome Centre and Genomic Medicine;

Department of Human Genetics Graduate School of Medicine University of Tokyo;

Department of Clinical Bioinformatics Graduate School of Medicine University of Tokyo;

Department of Metabolic Diseases Graduate School of Medicine University of TokyoCore Research for Evolution Science and Technology (CREST) Japan Science and Technology Corporation (JST);

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正文语种 eng
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关键词
Association; Polymorphism; Susceptibility gene;

机译：关联多态性易感基因;

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1. A comprehensive investigation of variants in genes encoding adiponectin ( ADIPOQ ) and its receptors ( ADIPOR1/R2 ), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome [J] . Kirsten E Peters, John Beilby, Gemma Cadby, BMC Medical Genetics . 2013,第1期

机译：对脂联素（ADIPOQ）及其受体（ADIPOR1 / R2）编码基因的变异及其与血清脂联素，2型糖尿病，胰岛素抵抗和代谢综合征的关系的全面研究
2. Association between the ?11377 C/G and ?11391 G/A polymorphisms of adiponectin gene and adiponectin levels with susceptibility to type 1 and type 2 diabetes mellitus in population from the west of Iran, correlation with lipid profile [J] . Nomani Hamid, Hesami Osman, Vaisi‐Raygani Asad, Journal of cellular biochemistry. . 2019,第3期

机译：α11377c / g与脂肪蛋白基因的多态性和脂联素水平与伊朗西部的1型和2型糖尿病患者，与脂质剖面相关
3. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab [J] . MatharooK., AroraP., BhanwerA.J.S. Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2013,第1期

机译：脂联素（AdipoQ）和磺酰脲受体（ABCC8）基因多态性与印度北部旁遮普邦的2型糖尿病的关系
4. Receptor for Advanced Gly cation End Product Polymorphisms and Type 2 Diabetes [C] . KATRIEN H.J. GAENS, CARLAJ.H. VAN DER KALLEN, MARLEEN M.J. VAN GREEVENBROEK, International Symposium on the Maillard Reaction . 2008

机译：高级Gly阳离子末端产物多态性的受体和2型糖尿病
5. Associations of Single Nucleotide Polymorphisms in the Bovine Prolactin, Melatonin Receptor 1A, and Dopamine Receptor D2 Genes with Hair Coat Shedding Scores and Productivity Traits in Beef Cattle. [D] . Meyer, Laura. 2016

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6. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2) and their association with serum adiponectin type 2 diabetes insulin resistance and the metabolic syndrome [O] . Kirsten E Peters, John Beilby, Gemma Cadby, 2013

机译：对脂联素（ADIPOQ）及其受体（ADIPOR1 / R2）编码基因的变异及其与血清脂联素2型糖尿病胰岛素抵抗和代谢综合征的关系的全面研究
7. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. [O] . Hara, K., Horikoshi, M., Kitazato, H., 2005

机译：编码脂联素受体的基因多态性与2型糖尿病之间没有关联。

Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes

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