Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1 −/− mice

摘要

Islets or beta cells from Sur1 −/− mice were used to determine whether changes in plasma membrane potential (V m) remain coupled to changes in cytosolic Ca2+ ([Ca2+]i) in the absence of KATP channels and thus provide a triggering signal for insulin secretion. The study also sought to elucidate whether [Ca2+]i influences oscillations in V m in sur1−/− beta cells.