Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men

摘要

The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-γ co-activator-1α (PPARGC1A or PGC1α), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes. Previous studies indicate that these risks depend on sex and environmental triggers such as age. The aim of the present study was to investigate the possible interactions between genotype and age and physical activity on risk of obesity.