Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2

A. J. K. Williams; R. J. Aitken; M. A.-M. Chandler; K. M. Gillespie; V. Lampasona; P. J. Bingley

首页> 外文期刊>Diabetologia >Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2

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Autoantibodies to islet antigen-2 are associated with HLA-DRB107 and DRB109 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2

机译：胰岛抗原2自身抗体与1型糖尿病发作时的HLA-DRB1 * 07和DRB1 * 09单倍型以及DRB1 * 04相关：HLA-DQA在对IA-2自身免疫中的可能作用

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Aims/hypothesis To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A).

机译：目的/假设为了进一步了解HLA II类分子对抗原的呈递，我们检查了HLA II类基因型对胰岛抗原2（IA-2A）自身抗体表达的影响。

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《Diabetologia》 |2008年第8期|p.1444-1448|共5页
作者
A. J. K. Williams; R. J. Aitken; M. A.-M. Chandler; K. M. Gillespie; V. Lampasona; P. J. Bingley;
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正文语种 eng
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关键词
HLA class II; IA; 2 autoantibodies; Juxtamembrane antibodies; Type 1 diabetes;

机译：HLA II类;IA;2种自身抗体;近膜抗体;1型糖尿病;

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1. Discovery of a novel HLA-DRB1*04:05 variant, DRB1*04:05:15, in a Taiwanese and the probable HLA haplotype in association with DRB1*04:05:15 [J] . YangK.L., LeeS.K., LinP.Y. International journal of immunogenetics . 2013,第5期

机译：在台湾发现新的HLA-DRB1 * 04：05变体DRB1 * 04：05：15，以及可能的HLA单倍体与DRB1 * 04：05：15相关
2. Discovery of the novel HLA-DRB1*10:04 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, -B, -C and -DRB1 haplotype in association with DRB1*10:04. [J] . K L Yang, S K Lee, R H Kao, International journal of immunogenetics . 2012,第5期

机译：在台湾志愿者骨髓供体中发现新型HLA-DRB1 * 10：04等位基因，并鉴定与DRB1 * 10：04相关的HLA-A，-B，-C和-DRB1单倍型。
3. Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population [J] . Furen Zhang, Hong Liu, Shumin Chen, BMC Medical Genetics . 2009,第1期

机译：HLA-DRB1 * 15和DRB1 * 09与麻风病相关的证据以及DRB1 * 09对中国汉族人群疾病发作的影响
4. Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population [O] . Furen Zhang, Hong Liu, Shumin Chen, 2009

机译：HLA-DRB1 * 15和DRB1 * 09与麻风病相关的证据以及DRB1 * 09对中国汉族人群疾病发作的影响
5. Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2 [O] . A. J. K. Williams, R. J. Aitken, M. A.-M. Chandler, 2008

机译：对胰岛抗原-2的自身抗体与HLA-DRB1 * 07和DRB1 * 09单倍型以及1型糖尿病的发作相关的DRB1 * 04：HLA-DQA在自身免疫中的可能作用对IA-2

Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2

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Autoantibodies to islet antigen-2 are associated with HLA-DRB107 and DRB109 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2