Leptin Secretion From Subcutaneous and visceral Adipose Tissue in Women

摘要

Upper body obesity is a risk factor for type 2 diabetes. Lit- tle is known about the regulation of body fat distribution, but leptin may be involved. This study examined the secretion of leptin in subcutaneous and omental fat tis- sue in 15 obese and 8 nonobese women. Leptin secrtion rates were two to three times higher in subcutaneous than in omental fat tissue in both obese and nonobese women (P<0.0001 and P<0.001, respectively). There was a positive correlation between BMI and leptin secre- tion rate sin both subcutaneous 9r=0.87, P<0.0001) and omental (r=0.74, P<0.0001) fat tissue.