Hypothalamic Corticotropin-Releasing Hormone Is a Mediator of the Anorexigenic Effect of Leptin

摘要

Leptin, ob gene product, inhibits feeding behavior and stimulates energy expenditure in rodents. Corti- cotropin-releasing hormone (CRH) and neuropeptide Y (NPY), which act in the hypothalamus to influence energy homeostasis, may mediate the anorexic effect of leptin. The present studies were undertaken to examine the possible involvement of hypothalamic CRH in the anorexigenic action of leptin in male Wistar rats. REcom- binant leptin (2 μg/rat), microinjected into the third ventricle, inhibited food intake at 2 h by 33.3/100 (P<0.01) in rats that were deprived of food for 18 h.