Phenotypic Characteristics Associated With Insulin Resistance in Metabolically Obese but Normal-Weight Young Women

摘要

Metabolically obese, normal-weight (MONW) individuals are a hypothesized subgroup of the general population. These normal-weight individuals potentially display a Cluster of obesity-related features, although this has not Been systematically tested in young women. We hypoth- Esized that MONW young women would display higher Levels of total and visceral fat and lower levels of phys- Ical activity than normal women. In a cohort of 71 Healthy nonobese women (21-35 years old), we identified MONW women based on cut points for insulin sensitiv- Ity (normal=glucose disposal >8 mg. Min~-1. Kg~-1 of fat- Free mass [FFM], n=58; impaired =glucose disposal <8 ml. min~-1. Kg~-1 of FFM, n=13).