Troglitazone, an Antidiabetic Agent, Inhibits Cholesterol Biosynthesis Through a Mechanism Independent of Peroxisome Proliferator-Activated Receptor-γ

摘要

Troglitazone is an antidiabetic agent of the thiazo- lidinedione family. It is generally believed that thiazo- lidinediones exert their insulin-sensitizing activity through activation of peroxisome proliferator-activated receptor-γ (PPAR-γ), a member of the steroid nuclear receptor superfamily. In the present study, we examined the effect of troglitazone on cholesterol biosynthesis in cultured Chinese hamster ovary (CHO) cell. Troglita- zone inhibited biosynthesis of cholesterol, but not that of total sterols, in a dose-dependent manner, with a half- maximal concentration (IC_50) value of 8 μmol/1.