Surgical Removal of Visceral Fat Reverses Hepatic Insulin Resistance

摘要

We directly examined whether visceral fat (VF) modu- lates hepatic insulin action by randomizing moderately obese (body wt ～400 g) Sprague-Dawley rats to either surgical removal of epididymal and perinephric fat pads (VF; n=9) or a sham operation (VF+; N=11). Three weeks later, total VF was fourfold increased (8.5 ±1.2 vs. 2.1 ±0.3 g, P<0.001) in the VF+ compared with the VF- group, but whole-body fat mass (determined using 3~H_2O) was not significantly different.