Effects of Recurrent Hypoglycemia on Brainstem Function in Diabetic BB Rats

摘要

To determine whether antecedent recurrent hypogly- cemia protects the brain from the adverse effects of a standardized hypoglycemic stimulus, we implanted electrodes in the inferior colliculi of diabetic rats to directly record inferior colliculi auditory-evoked potentials (ICEPs). Awake, chronically catheterized BB rats were studied after 2 weeks of insulin therapy Designed to produce either chronic hyperglycemia (hyper-DM, glycated hemoglobin 7.6±0.4/100) or recur- rent hypoglycemia (hypo-DM, glycated hemoglobin 6.2 ±0.7/100), and the results were compared with those observed in nondiabetic rats.