Induction of Insulin Resistane by Glucosamine Reduces Blood Flow but Not Interstitial Levels of Either Glucose or Insulin

摘要

To study the effects of a glucosamine infusion on skele- tal muscle metabolism, microdialysis was performed in the medial femoral muscle in Sprague-Dawley rats dur- ing a euglycemic-hyperinsulinemic clamp (insulin infu- sion 18 mU. Kg~-1. Min~-1). During steady-state clamping conditions (70 min), an infusion of glucosamine (30 μmol. Kg~-1. Min~-1) or saline was given for 240 min. Blood flow was measured by the microsphere technique At the end of the clamp. An ～36/100 (P<0.001) reduction In the glucose infusion rate was seen after 170 min in The glucosamine-treated rats compared with control Rats.