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Kinetics of GLUT4 Trafficking in Rat and Human Skeletal Muscle

机译：GLUT4在大鼠和人骨骼肌中的运动动力学

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摘要

In skeletal muscle, insulin stimulates glucose transport activity three- to fourfold, and a large part of this stimulation is associated with a net translocation of GLUT4 from an intracellular compartment to the cell surface. We examined the extent to which insulin or the AMP-activated protein kinase activator AICAR can lead to a stimulation of the exocytosis limb of the GLUT4 translocation pathway and thereby account for the net increase in glucose transport activity.
机译：在骨骼肌中，胰岛素刺激三到四倍的葡萄糖转运活性，并且这种刺激的很大一部分与GLUT4从细胞内腔室到细胞表面的净移位有关。我们研究了胰岛素或AMP激活的蛋白激酶激活剂AICAR可以刺激GLUT4易位途径的胞吐作用肢体的程度，从而解释了葡萄糖转运活性的净增加。

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  • 来源
    《Diabetes》 |2009年第4期|p.847-854|共8页
  • 作者

    Håkan K R Karlsson Alexander V Chibalin Heikki A Koistinen Jing Yang Francoise Koumanov Harriet Wallberg-Henriksson Juleen R Zierath Geoffrey D Holman;

  • 作者单位

    Hakan K.R. Karlsson,1 Alexander V. Chibalin,1 Heikki A. Koistinen,1,2,3 Jing Yang,4 Françoise Koumanov,4 Harriet Wallberg-Henriksson,5 Juleen R. Zierath,1 and Geoffrey D. Holman4From the 1 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, the 2 Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland, the 3 Minerva Foundation Institute for Medical Research, Biomedicum 2U Helsinki, Helsinki, Finland, the 4 Department of Biology and Biochemistry, University of Bath, Bath, U.K., and the 5 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.Corresponding author: Geoffrey D. Holman, g.d.holman@bath.ac.uk.Received 5 November 2008 and accepted 19 January 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 2 February 2009. DOI: 10.2337/db08-1539.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:51

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