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Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia

机译:脑胰岛素的作用调节下丘脑葡萄糖的感觉和对低血糖的反调节反应。

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摘要

An impaired ability to sense and appropriately respond to insulin-induced hypoglycemia is a common and serious complication faced by insulin-treated diabetic patients. This study tests the hypothesis that insulin acts directly in the brain to regulate critical glucose-sensing neurons in the hypothalamus to mediate the counterregulatory response to hypoglycemia.
机译:胰岛素治疗的糖尿病患者面临的常见且严重的并发症是感知和适当响应胰岛素诱发的低血糖的能力受损。这项研究检验了以下假设:胰岛素直接在大脑中起作用,以调节下丘脑中的关键葡萄糖敏感神经元,从而介导对低血糖的反调节反应。

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  • 来源
    《Diabetes》 |2010年第9期|p.2271-2280|共10页
  • 作者单位

    Kelly A. Diggs-Andrews,1 Xuezhao Zhang,1 Zhentao Song,2 Dorit Daphna-Iken,1 Vanessa H. Roiith,' and Simon J. Fisher1,3From the 1 Division of Endocrinology, Metabolism and Lipid Research, Department of Internal Medicine. Washington University School of Medicine, Saint Louis, Missouri, the -Department of Pharmacology and Physiology, New Jersey Medical School (UMDNJ), Newark, New Jersey, and the department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri.Corresponding author: Simon J. Fisher, sfisher@dom.wustl.edu.Received 22 March 2010 and accepted 4 June 2010. Published ahead of print at. http://diabetes.diabetesjounials.org on 14 June 2010. DOI: 10.2337/ db10-0401.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:43

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