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Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

机译:尽管有免疫抑制,但同时胰腺-肾脏移植后1型糖尿病的复发与自身抗体和致病性自身反应性CD4 T细胞相关

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摘要

To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients.
机译:为了研究复发性自身免疫是否解释了三例免疫抑制的同时胰腺-肾脏(SPK)移植受者的高血糖和C肽丢失。

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  • 来源
    《Diabetes》 |2010年第4期|p.947-957|共11页
  • 作者单位

    Francesco Vendrame,1 Antonello Pileggi,1'2 Elsa Laughlin,3 Gloria Allende,1 Ainhoa Martin-Pagola,1 R. Damaris Molano,1 Stavros Diaman topoulos,1 Nathan Standifer,3,4 Kelly Geubtner,3 Ben A. Falk,3 Hirohito Ichii,1,2 Hidenori Takahashi,2 Isaac Snowhite,1 Zhibin Chen,5 Armando Méndez,1'6 Linda Chen,2 Junichiro Sageshima,2 Phillip Ruiz,2 Gaetano Ciancio,2 Camillo Ricordi,1'2'5,6 Helena Reijonen,3 Gerald T. Nepom,3 George W. Burke III,1'2 and Alberto Pugliese1'5'6From the lDiabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, the 2Department of Surgery, Division of Transplantation, Leonard Miller School of Medicine, University of Miami, Miami, Florida, the 'Benaroya Research Institute, Seattle, Washington, ''Clinical biimunology, Amgen Inc., Seattle, Washington, the "Department of Microbiology and Immunology, Leonard Miller School of Medicine, University of Miami, Miami, Florida, and the "Department of Medicine, Division of Endocrinology and Metabolism. Leonard Miller School of Medicine, University of Miami, Miami, Florida.Corresponding author Alberto Pugliese, apugUes@med.nuami.edu.Received 3 April 2009 and accepted 6 January 2010. Published ahead of print at http://diabetes.diabetesjotunaIs.org on 19 January 2010. DOi: 10.2337/ db09-0498.F. V. and A-Pi. contributed equally to this work. G.W.B. and A. Pu. were co-principal investigators and contributed equally to this work.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The cosls of publication of this article were defrayed in part by lhe payment of paye charges. Tliis article must therefore be hereby marked "advertisement" hi accordance with IS U.S.C. Section 17?1 solely Io indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:41

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