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首页> 外文期刊>Diabetes >Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis
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Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis

机译：巨噬细胞脂联素表达提高胰岛素敏感性，并防止炎症和动脉粥样硬化

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摘要

Adiponectin is one of several important metabolically active cytokines secreted from adipose tissue. Epidemiologic studies have associated low-circulating levels of this adipokine with multiple metabolic disorders including obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. To investigate adiponectin-mediated changes in metabolism in vivo, we generated transgenic mice that specifically express the gene coding for human adiponectin in mouse macrophages using the human scavenger receptor A-I gene enhancer/promoter.
机译：脂联素是从脂肪组织分泌的几种重要的代谢活性细胞因子之一。流行病学研究已将这种脂肪因子的低循环水平与多种代谢异常相关，包括肥胖，胰岛素抵抗，2型糖尿病和心血管疾病。为了研究脂联素介导的体内代谢变化，我们使用人清道夫受体A-I基因增强子/启动子产生了在小鼠巨噬细胞中特异性表达编码人脂联素基因的转基因小鼠。

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  • 来源
    《Diabetes》 |2010年第4期|p.791-799|共9页
  • 作者

    Nanlan Luo Jian Liu B Hong Chung Qinglin Yang Richard L Klein W Timothy Garvey Yuchang Fu;

  • 作者单位

    Nanlan Luo,1 Jian Liu,1 B. Hong Chung,1 Qinglin Yang,1 Richard L. Klein,2 W. Timothy Garvey,1,3 and Yuchang Fu1From the 'Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, the department of Medicine, Medical University of South Carolina, Charleston, South Carolina, and the Ralph H. Johnson Department of Veteran Affairs Medical Center, Charleston, South Carolina, and the Birmingham Veterans Affairs Medical Center, Birmingham, AlabamaCorresponding author Yuchang Fu, yfu@uab.edu.Received 10 September 2009 and accepted 24 December 2009.DOI: 10.2337/db09-1338© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See hrtp,//creativecommons.org/lieenses/by -nc-nd/3.0/ for détails.The costs of publication of this article were defrayed m part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:40

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