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Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

机译:CYP2J3表达增加会降低果糖治疗大鼠和db / db小鼠的胰岛素抵抗

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摘要

Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play crucial and diverse roles in cardiovascular homeostasis. The anti-inflammatory, antihypertensive, and pro-proliferative effects of EETs suggest a possible beneficial role for EETs on insulin resistance and diabetes.
机译:越来越多的证据表明,细胞色素P450(CYP)环氧合酶将花生四烯酸代谢为环氧二十碳三烯酸(EET),这在心血管稳态中起着至关重要的作用。 EET的抗炎,抗高血压和促增殖作用表明EET对胰岛素抵抗和糖尿病可能具有有益作用。

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  • 来源
    《Diabetes》 |2010年第4期|p.997-1005|共9页
  • 作者单位

    Xizhen Xu,1 Chun Xia Zhao,1 Luyun Wang,1 Ling Tu,1 Xiaosai Fang,1 Changlong Zheng,1 Matthew L. Edin,2 Darryl C. Zeldin,2 and Dao Wen Wang1From the 'Department of Internal Medicine and The Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China, and the 2 Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North CarolinaCorresponding author Dao Wen Wang, dwwang@tjh.tjmu.edu.cn.Received 27 August 2009 and accepted 21 December 2009. Published ahead of print at http://diabetes.diabetesjournals.org on 12 January 2010. DOI: 10.2337/db09-1241.XX., CXZ., and LW. contributed equally to this study.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http-7/creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with IS U.S.C. Section 173U solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 入库时间 2022-08-17 13:45:39

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