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Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

机译：长寿相关蛋白Sirtuin 1在胰岛素抵抗和代谢综合征中的下调：潜在的生化机制。

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摘要

Sirtuins (SIRTs) are NAD(+)-dependent deacetylases that regulate metabolism and life span. We used peripheral blood mononuclear cells (PBMCs) to determine ex vivo whether insulin resistance/metabolic syndrome influences SIRTs. We also assessed the potential mechanisms linking metabolic alterations to SIRTs in human monocytes (THP-1) in vitro.
机译：Sirtuins（SIRTs）是NAD（+）依赖性脱乙酰基酶，调节新陈代谢和寿命。我们使用外周血单核细胞（PBMC）来确定离体胰岛素抵抗/代谢综合征是否会影响SIRT。我们还评估了潜在的机制，将代谢变化与人类单核细胞（THP-1）中的SIRTs联系起来。

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  • 来源
    《Diabetes》 |2010年第4期|p.1006-1015|共10页
  • 作者

    Saula Vigili de Kreutzenberg Giulio Ceolotto Italia Papparella Alessia Bortoluzzi Andrea Semplicini Chiara Dalla Man Claudio Cobelli Gian Paolo Fadini Angelo Avogaro;

  • 作者单位

    Saula Vigili de Kreutzenberg,1 Giulio Ceolotto,1 Italia Papparella,1 Alessia Bortoluzzi,1 Andrea Semplicini,1 Chiara Dalla Man,2 Claudio Cobelli,2 Gian Paolo Fadini,1 and Angelo Avogaro1From the 1 Department of Clinical and Experimental Medicine, Metabolic Diseases, University of Padova, Padova, Italy, and the 2 Department of Information Engineering, University of Padova, Padova, Italy.Corresponding author Saula Vigili de Kreutzenberg, sauladekreutzenberg@ unipd.itReceived 10 August 2009 and accepted 21 December 2009. Published ahead of print at http^/diabetes.diabetesjoumals.org on 12 January 2010. DOI: 10.2337/db09-1187.S.V.d.K. and G.C. contributed equally to this study.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creaüvecommons.orgAicenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part, by the payment of paye charges. This article must therefore be hereby marked "advertisement'' in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:38

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