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Detailed Investigation of the Role of Common and Low-Frequency WFS1 Variants in Type 2 Diabetes Risk

机译:常见和低频WFS1变异在2型糖尿病风险中的作用的详细调查

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摘要

Wolfram syndrome 1 (WFS1) single nucleotide polymorphisms (SNPs) are associated with risk of type 2 diabetes. In this study we aimed to refine this association and investigate the role of low-frequency WFS1 variants in type 2 diabetes risk.
机译:Wolfram综合征1(WFS1)单核苷酸多态性(SNP)与2型糖尿病的风险相关。在这项研究中,我们旨在完善这种联系,并研究低频WFS1变异在2型糖尿病风险中的作用。

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  • 来源
    《Diabetes》 |2010年第3期|p.741-746|共6页
  • 作者单位

    Katherine A. Fawcett,1 Eleanor Wheeler,1 Andrew P. Morris,2 Sally L. Ricketts,3 Goran Hallmans,4 Olov Rolandsson,5 Allan Daly,1 Jon Wasson,6 Alan Permuti,7 Andrew T. Hattersley,8 Benjamin Glaser,9 Paul W. Franks,1011 Mark I. McCarthy,12'13·14 Nicholas J. Wareham,15 Manjinder S. Sandhu,3'15 and Inés Barroso1From the 'Metabolic Disease Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, U.K., the ^Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K., the ''Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, U.K., the 4SeCUOn for Nutritional Research, Department of Public Health & Clinical Medicine, Umeá University Hospital, Umeâ, Sweden, the "Section for Family Medicine, Department of Public Health & Clinical Medicine, Umeâ University Hospital, Umeâ, Sweden, the r,Department of Medicine, Metabolism, Diabetes and Lipid Research Division, Washington University School of Medicine, Saint Louis, Missouri, the 7Department of Internal Medicine, Metabolism, Diabetes and Lipid Research Division, Washington University School of Medicine, Saint Louis, Missouri, the 8Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, U.K., the ^Endocrine and Metabolism Service, The Hadassah Hebrew University Medical Center, Jerusalem, Israel, the '"Section for Medicine, Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeâ University Hospital, Umeâ, Sweden, the "Section for Nutritional Research, Department of Public Health & Clinical Medicine, Umeâ University Hospital, Umeâ Sweden, the 12Oxford Centre for Diabetes Endocrinology & Metabolism, Churchill Hospital, University of Oxford, Oxford, U.K., the "Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Headington, Oxford, U.K., the "Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, U.K., and the IBMedical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, U.K.Corresponding author Inés Barroso, ibl@sanger.ac.uk.Received 22 June 2009 and accepted 10 December 2009. Published ahead of print at http://diabetes.diabetesjournals.org on 12 December 2009. DOI: 10.2ä37/db09-0920.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by lite payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with i8 U.S.C. Section I7iH solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 入库时间 2022-08-17 13:45:42

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