Pharmacokinetics and Pharmacrodynamics of Subcutaneous Injection of Long-Acting Human Insulin Analog Glargine, NPH Insulin, and Ultralente Human Insulin and Continuous Subcutaneous Infusion of Insulin Lispro

摘要

To compare the pharmacokinetics/dynamics of the long- acting insulin analog glargine with NPH, ultralente, and continuous subcutaneous (SC) infusion of insulin lispro (continuous subcutaneous insulin infusion [CSII]), 20 C-peptide-negative type 1 diabetic patients were stud- Ied on four occasions during an isoglycemic 24-h clamp. Patients received SC injection of either 0.3 U/kg Glargine or NPH insulin (rnadom sequence, crossover Design).