Rapid Publication Activation of Glucose Transport by AMP-Activated Protein Kinase via Stimulation of Nitric Oxide Synthase

摘要

Glucose transport in skeletal muscle is stimulated by two distinct stimuli, insulin and exercise. The mechanism by which exercise stimulates glucose transport is not known, although it is distinct from the insulin-mediated pthway. Recetly, it has been shown that AMP-activated protin kinase (AMPK) is activated by exercise in skele- tal muscle, whereas pharmacological activation of AMPK by 5-amino-4-imidazolecarboxamide riboside (AICAR) leads to increased glucose transport.